Hemocompatibility of surface-modified, silicon-incorporated, diamond-like carbon films

Title
Hemocompatibility of surface-modified, silicon-incorporated, diamond-like carbon films
Authors
R.K. RoyH.W. Choi이진우문명운이광렬한동근신지훈A. KamijoT. Hasebe
Keywords
DLC; biocompatibility; stent; NiTi; surface modification; hydrophilic; hemocompatibility; platelet adhesion; polar component; diamond-like carbon
Issue Date
2009-01
Publisher
Acta Biomaterialia
Citation
VOL 5, NO 1, 249-256
Abstract
The hemocompatibility of plasma-treated, silicon-incorporated, diamond-like carbon (Si-DLC) films was investigated. Si-DLC films with a Si concentration of 2 at.% were prepared on Si (100) or Nitinol substrates using a capacitively coupled radiofrequency plasmaassisted chemical vapor deposition method using a mixed gas of benzene (C6H6) and diluted silane (SiH4:H2 = 10:90). The Si-DLC films were then treated with O2, CF4 or N2 glow discharge for surface modification. The plasma treatment revealed an intimate relationship between the polar component of the surface energy and its hemocompatibility. All in vitro characterizations, i.e. protein absorption behavior, activated partial thromboplastin time measurement and platelet adhesion behavior, showed improved hemocompatibility of the N2-- or O2-plasma-treated surfaces where the polar component of the surface energy was significantly increased. Si–O or Si–N surface bonds played an important role in improving hemocompatibility, as observed in a model experiment. These results support the importance of a negatively charged polar component of the surface in inhibiting fibrinogen adsorption and platelet adhesion.
URI
http://pubs.kist.re.kr/handle/201004/34682
ISSN
1742-7061
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KIST Publication > Article
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