Synthesis of 10-substituted triazolyl artemisinins possessing anticancer activity via Huisgen 1,3-dipolar cylcoaddition

Title
Synthesis of 10-substituted triazolyl artemisinins possessing anticancer activity via Huisgen 1,3-dipolar cylcoaddition
Authors
조성식오상태엄유미정지희함정엽신운섭이석준
Keywords
triazolyl artemisinin; anticancer activity; Huisgen 1,3-dipolar cylcoaddition; natural product
Issue Date
2009-01
Publisher
Bioorganic & medicinal chemistry letters
Citation
VOL 19, NO 2, 382-385
Abstract
Most of the 10-substituted triazolylartemisinin synthesized via the Huisgen 1,3-dipolar cylcoaddition of diastereomeric 10-azidoartemisinin (5, 6, and 7) with various alkynes (a–h) exhibit strong growth inhibition activity, even at sub-micromolar concentrations, against various cancer cell lines such as DLD-1, U-87, Hela, SiHa, A172, and B16. In particular, 10b and 10f showed a highly strong cytotoxicity.
URI
http://pubs.kist.re.kr/handle/201004/34879
ISSN
0960-894X
Appears in Collections:
KIST Publication > Article
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