Developmental and Osteoarthritic Changes in Col6a1-Knockout Mice
- Developmental and Osteoarthritic Changes in Col6a1-Knockout Mice
- L. G. Alexopoulos; 윤인찬; Paolo Bonaldo; Farshid Guilak
- Issue Date
- Arthritis and rheumatism
- VOL 60, NO 3, 771-779
- Objective. Chondrocytes, the sole cell type in articular cartilage, maintain the extracellular matrix (ECM) through a homeostatic balance of anabolic and catabolic activities that are influenced by genetic factors, soluble mediators, and biophysical factors such as mechanical stress. Chondrocytes are encapsulated by a narrow tissue region termed the “pericellular matrix” (PCM), which in normal cartilage is defined by the exclusive presence of type VI collagen. Because the PCM completely surrounds each cell, it has been hypothesized that it serves as a filter or transducer for biochemical and/or biomechanical signals from the cartilage ECM. The present study was undertaken to investigate whether lack of type VI collagen may affect the development
and biomechanical function of the PCM and alter the mechanical environment of chondrocytes during joint loading.
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