Extraction of bioactive components from Centella asiatica using subcritical water

Title
Extraction of bioactive components from Centella asiatica using subcritical water
Authors
김완주김재훈밤방김재덕이윤우오성근R. Tjandrawinata
Keywords
Subcritical water; Centella Asiatica; Extraction; Water; asiatic acid; asiaticoside; particle formation
Issue Date
2009-04
Publisher
The Journal of supercritical fluids
Citation
VOL 48, NO 3, 211-216
Abstract
Bioactive components, asiatic acid and asiaticoside,were extracted fromCentella asiatica using subcritical water as an extraction solvent. Extraction yields of asiatic acid and asiaticoside were measured using high-performance liquid chromatography (HPLC) at temperatures from 100 to 250 ◦C and pressures from 10 to 40MPa. As temperature or pressure increased, the extraction yield of asiatic acid and asiaticoside increased. At the optimal extraction conditions of 40MPa and 250 ◦C, the extraction yield of asiatic acid was 7.8 mg/g and the extraction yield of asiaticosidewas 10.0 mg/g. Extracted asiatic acid and asiaticoside could be collected from water as particles with a simple filtering process. Dynamic light scattering (DLS) was used to characterize particle size. Particles containing asiatic acidwere larger (1.21 m) than particles containing asiaticoside (0.76 m). The extraction yields of asiatic acid and asiaticoside using subcritical water at 40MPa and 250 ◦Cwere higher than extraction yields using conventional liquid solvent extraction with methanol or ethanol at room temperature while the subcritical water extraction yields were lower than extraction yields with methanol or ethanol at its boiling point temperature.
URI
http://pubs.kist.re.kr/handle/201004/35021
ISSN
0896-8446
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KIST Publication > Article
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