Functional PLGA Scaffolds for Chondrogenesis of Bone-Marrow-derived Mesenchymal Stem Cell
- Functional PLGA Scaffolds for Chondrogenesis of Bone-Marrow-derived Mesenchymal Stem Cell
- 박귀덕; 조경진; 김재진; 김익환; 한동근
- drug delivery systems; structure; supports; surfaces; tissue engineering
- Issue Date
- Macromolecular bioscience
- VOL 9, NO 3, 221-229
- Two chondrogenic factors, Dex and TGF-b1, were incorporated into PLGA scaffolds and their
chondrogenic potential was evaluated. The Dex-loaded PLGA scaffold was grafted with AA and
heparin, the heparin-immobilized one was then reacted with TGF-b1, yielding a PLGA/Dex-
TGF (PLGA/D/T) scaffold. The scaffolds were seeded with rabbit MSCs and cultured for 4 weeks. The results show that the scaffolds including chondrogenic factors strongly upregulated the expression of cartilage-specific genes and clearly displayed type-II collagen immunofluorescence. The functionalized PLGA scaffolds could provide an appropriate niche for chondrogenic differentiation of MSC without a constant medium supply of Dex and TGF-b1.
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