Functional PLGA Scaffolds for Chondrogenesis of Bone-Marrow-derived Mesenchymal Stem Cell

Title
Functional PLGA Scaffolds for Chondrogenesis of Bone-Marrow-derived Mesenchymal Stem Cell
Authors
박귀덕조경진김재진김익환한동근
Keywords
drug delivery systems; structure; supports; surfaces; tissue engineering
Issue Date
2009-03
Publisher
Macromolecular bioscience
Citation
VOL 9, NO 3, 221-229
Abstract
Two chondrogenic factors, Dex and TGF-b1, were incorporated into PLGA scaffolds and their chondrogenic potential was evaluated. The Dex-loaded PLGA scaffold was grafted with AA and heparin, the heparin-immobilized one was then reacted with TGF-b1, yielding a PLGA/Dex- TGF (PLGA/D/T) scaffold. The scaffolds were seeded with rabbit MSCs and cultured for 4 weeks. The results show that the scaffolds including chondrogenic factors strongly upregulated the expression of cartilage-specific genes and clearly displayed type-II collagen immunofluorescence. The functionalized PLGA scaffolds could provide an appropriate niche for chondrogenic differentiation of MSC without a constant medium supply of Dex and TGF-b1.
URI
http://pubs.kist.re.kr/handle/201004/35165
ISSN
1616-5187
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KIST Publication > Article
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