Determination of mirodenafil and sildenafil in the plasma and corpus cavernous of SD male rats

Title
Determination of mirodenafil and sildenafil in the plasma and corpus cavernous of SD male rats
Authors
이상규김윤김태곤임광진이봉룡김동현진창배유혜현
Keywords
Mirodenafil; Sildenafil; Tissue distribution; LC?S/MS
Issue Date
2009-02
Publisher
Journal of pharmaceutical and biomedical analysis
Citation
VOL 49, NO 2, 513-518
Abstract
The purpose of the present study was to determine sildenafil and a novel PDE-5 inhibitor, mirodenafil in the plasma and corpus cavernosum tissue of rats to compare their pharmacokinetic properties. The concentrations of mirodenafil and sildenafil in the rat plasma and corpus cavernosum tissue samples were analyzed using LC–MS/MS after a single oral administration at a dose of 40 mg/kg to rats. Although the Tmax, T 1/2 and MRT were not different between mirodenafil and sildenafil, the Cmax and AUC of mirodenafilwere significantly higher than those of sildenafil in the plasma and corpus cavernosum tissue. Consequently mirodenafil remained longer than sildenafil in the plasma and tissue. This may provide pharmacokinetic evidence for assessment of the in vivo efficacy of mirodenafil and sildenafil.
URI
http://pubs.kist.re.kr/handle/201004/35267
ISSN
0731-7085
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KIST Publication > Article
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