Detox agents do not affect the pharmacokinetics of methamphetamine in the rat
- Detox agents do not affect the pharmacokinetics of methamphetamine in the rat
- 이상규; 김윤; 서승일; 서용준; 인문교; 김동현; 진창배; 유혜현
- Detox agents; Methamphetamine; Amphetamine; Elimination; Drug test
- Issue Date
- Forensic science international
- VOL 186, e21-e24
- Recently, ‘detox’ agents have been popularly used as forms of diets or nutritional supplements.
Especially, several cases have been reported that these detox agents have been used to mask drug tests
among drug abusers. In the present study, capsule and drink types of detox agents were evaluated for
their ability to alter the elimination of methamphetamine (MA) in rats. For this study, MA and its major
metabolite, amphetamine (AP) in urine samples were determined using LC–tandem mass spectrometry
after administration of the detox agents to MA-treated rats. As a result, significant differences were not
shown between control and detox-dosed groups in the amounts of MAand AP excreted into urine as well
as the volume of excreted urine. This result suggests that the detox agents tested may not affect the
metabolism or elimination of MA and further might have minimal effect on narcotics detection in the
urine samples of drug abusers.
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