Detox agents do not affect the pharmacokinetics of methamphetamine in the rat

Title
Detox agents do not affect the pharmacokinetics of methamphetamine in the rat
Authors
이상규김윤서승일서용준인문교김동현진창배유혜현
Keywords
Detox agents; Methamphetamine; Amphetamine; Elimination; Drug test
Issue Date
2009-04
Publisher
Forensic science international
Citation
VOL 186, e21-e24
Abstract
Recently, ‘detox’ agents have been popularly used as forms of diets or nutritional supplements. Especially, several cases have been reported that these detox agents have been used to mask drug tests among drug abusers. In the present study, capsule and drink types of detox agents were evaluated for their ability to alter the elimination of methamphetamine (MA) in rats. For this study, MA and its major metabolite, amphetamine (AP) in urine samples were determined using LC–tandem mass spectrometry after administration of the detox agents to MA-treated rats. As a result, significant differences were not shown between control and detox-dosed groups in the amounts of MAand AP excreted into urine as well as the volume of excreted urine. This result suggests that the detox agents tested may not affect the metabolism or elimination of MA and further might have minimal effect on narcotics detection in the urine samples of drug abusers.
URI
http://pubs.kist.re.kr/handle/201004/35269
ISSN
0379-0738
Appears in Collections:
KIST Publication > Article
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