Aminoquinoline Derivatives with Antiproliferative Activity Against Melanoma Cell Line

Title
Aminoquinoline Derivatives with Antiproliferative Activity Against Melanoma Cell Line
Authors
남봉수김환오창현이소하조승주심태보하정미김동진최정훈유경호
Keywords
Aminoquinolines; Antiproliferative activity; Melanoma cell line; Fibroblast cell line; Selectivity
Issue Date
2009-07
Publisher
Bioorganic & medicinal chemistry letters
Citation
VOL 19, NO 13, 3517-3520
Abstract
The synthesis of a novel series of aminoquinoline derivatives 1a–p and their antiproliferative activities against A375 human melanoma cell line were described. Most compounds showed superior antiproliferative activities to Sorafenib as a reference compound. Among them, quinolinyloxymethylphenyl compounds 1k and 1l exhibited potent activities (IC50 = 0.77 and 0.79 lM, respectively) and excellent selectivity against melanoma and fibroblast cell lines.
URI
http://pubs.kist.re.kr/handle/201004/35436
ISSN
0960-894X
Appears in Collections:
KIST Publication > Article
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