MONITORING OF POPs FROM BIOLOGICAL FLUIDS USING HS SPME-GC/MS
- MONITORING OF POPs FROM BIOLOGICAL FLUIDS USING HS SPME-GC/MS
- 채효진; 김승기; 표희수; 홍종기
- Issue Date
- 18th Symposium on Environmental Chemistry
- , 936-937
- Rapid industrialization resulted in increasing levels of industrial by-products, including
organochlorine pesticides (OCPs) and polychlorinated biphenyls (PCBs) in the environment and
human compartments. OCPs are typical persistent organic pollutants with toxicity and
bioaccumulation properties. Although the production of most OCPs has been banned for decades,
they are still found in the environment due to their high persistence. The exposure of OCPs to
human beings is predominantly processed through foodstuffs. PCBs make up a group of 209
individual chlorinated biphenyl rings known as congeners. The effect of exposure is liver damage,
estrogenicity, thiroxine reduction. And major exposure is drinking water, food, skin contact,
breathing air and bioaccumulation (mainly fat and liver).
We developed analytical method for 18 OCPs and 16 PCBs determination in biological fluids,
human whole blood, using headspace solid phase extraction gas chromatograph / mass
spectrometer (HS SPME-GC/MS). We investigated the optimization of HS-SPME conditions, the
method validation (MDL, calibration, linearity) and applied them to human blood for the
monitoring of OCPs and PCBs.
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