Synthesis of sulfonyl curcumin mimics exerting a vasodilatation effect on the basilar artery of rabbits

Title
Synthesis of sulfonyl curcumin mimics exerting a vasodilatation effect on the basilar artery of rabbits
Authors
안찬묵박병곤우호범함정엽신운섭이석준
Keywords
Organic synthesis; Curcumin; Sulfonyl curcumin mimics; Vasodilatation; Basilar artery
Issue Date
2009-03
Publisher
Bioorganic & medicinal chemistry letters
Citation
VOL 19, NO 5, 1481-1483
Abstract
In order to discover novel small vasodilatory molecules for potential use in the treatment of vascular disease, we tested the vasodilatation effect of two types of synthetic curcumin mimics, amide type (3) and sulfonyl amide type (4), upon the basilar artery of rabbits. In general, the sulfonyl amide type mimic (4) is more potent than the amide type (3). Curcumin (1) and compounds 12 and 20 effectively dilated the basilar artery of white rabbits
URI
http://pubs.kist.re.kr/handle/201004/35538
ISSN
0960-894X
Appears in Collections:
KIST Publication > Article
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