An Electronic Traveler Aid For The Blind Using Multiple Range Sensors

Title
An Electronic Traveler Aid For The Blind Using Multiple Range Sensors
Authors
김래현박세형이수용하성도
Keywords
electronic travel aids; blind people; range sensor
Issue Date
2009-06
Publisher
IEICE Electronics Express
Citation
VOL 6, NO 11, 794-799
Abstract
In this study, we investigated the effects of various histone deacetylase (HDAC) inhibitors on adipocyte differentiation. Treatment of 3T3-L1 cells with HDAC inhibitors such as apicidin, trichostatin A, or suberoylanilide hydroxamic acid, under conditions that normally promote differentiation led to a dramatic attenuation of adipocyte differentiation. In contrast, sodium butyrate (NaB) treatment increased adipocyte differentiation. Accordingly, the expression of adipogenic marker genes such as FAS, aP2, PPARγ, resistin, C/EBPα, ADD1/SREBP1c, and adiponectin were inhibited by apicidin treatment but not NaB, indicating that the adipocyte differentiation process could be differentially regulated depending on the type of HDAC inhibitor utilized. In addition, this differential effect seemed not to be due to disruption of the insulin- signaling pathway. Interestingly, our data showed that apicidin treatment could induce dedifferentiation of fully differentiated adipocytes, as evident by the fact that apicidin treatment led to a decrease of Oil Red O-stained adipocytes with a concomitant reduction in the expression levels of adipogenic marker genes. Collectively, our results suggest that adipocyte differentiation and dedifferentiation may be regulated by HDAC inhibitors. Key words: Adipocyte differentiation, Dedifferentiation, HDAC inhibitors, Apicidin,
URI
http://pubs.kist.re.kr/handle/201004/35543
ISSN
1349-2543
Appears in Collections:
KIST Publication > Article
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