Quorum sensing in butanol producing clostridia during batch fermentation and its relationships with the capability of butanol production
- Quorum sensing in butanol producing clostridia during batch fermentation and its relationships with the capability of butanol production
- 이선미; 조민옥; 박성수; 엄영순; 상병인
- butanol; quorum sensing
- Issue Date
- 2009 The Korean Society for Microbiology and Biotechnology International Symposium and Annual Meeting
- Butanol producing clostridia utilize sugar as substrate and produce acids that include acetic acid and butyric acid during the initial phase of exponential growth. When the concentration of acids has reached a certain threshold, clostridia switch to solvent production. This switching is mediated by the genes related to solvent production, such as crfA, crfB, and aad in Clostridium acetobutylicum ATCC 824. At the time, quorum sensing related luxS gene also expresses with solvent production during batch fermentation. In this study, we investigated the production of quorum sensing signal molecule, autoinduder-2 (AI-2), in Clostridium acetobutylicum ATCC 824, Clostridium beijerinckii NCIMB 8052, and nonsolventogenic Clostridium acetobutylicum (M5) during biobutanol production. Interestingly, the AI-2 production in solventogenic clostridia was initiated with solvent production during batch fermentation. However, nonsolventogenic clostridia (M5) did not seem to produce AI-2 during their cell cycle. This study shows, therefore, the possibility of quorum sensing as a monitoring technique for the butanol producing capability in solventogenic clostridia.
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