Quorum sensing in butanol producing clostridia during batch fermentation and its relationships with the capability of butanol production

Title
Quorum sensing in butanol producing clostridia during batch fermentation and its relationships with the capability of butanol production
Authors
이선미조민옥박성수엄영순상병인
Keywords
butanol; quorum sensing
Issue Date
2009-06
Publisher
2009 The Korean Society for Microbiology and Biotechnology International Symposium and Annual Meeting
Abstract
Butanol producing clostridia utilize sugar as substrate and produce acids that include acetic acid and butyric acid during the initial phase of exponential growth. When the concentration of acids has reached a certain threshold, clostridia switch to solvent production. This switching is mediated by the genes related to solvent production, such as crfA, crfB, and aad in Clostridium acetobutylicum ATCC 824. At the time, quorum sensing related luxS gene also expresses with solvent production during batch fermentation. In this study, we investigated the production of quorum sensing signal molecule, autoinduder-2 (AI-2), in Clostridium acetobutylicum ATCC 824, Clostridium beijerinckii NCIMB 8052, and nonsolventogenic Clostridium acetobutylicum (M5) during biobutanol production. Interestingly, the AI-2 production in solventogenic clostridia was initiated with solvent production during batch fermentation. However, nonsolventogenic clostridia (M5) did not seem to produce AI-2 during their cell cycle. This study shows, therefore, the possibility of quorum sensing as a monitoring technique for the butanol producing capability in solventogenic clostridia.
URI
http://pubs.kist.re.kr/handle/201004/35559
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KIST Publication > Conference Paper
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