Production of chromopyrrolic acid by coexpression of inkOD in a heterologous host Streptomyces albus

Title
Production of chromopyrrolic acid by coexpression of inkOD in a heterologous host Streptomyces albus
Authors
채충식박진수정순천김태임이소형윤경미신종헌오기봉
Keywords
K252a; Heterologous expression; Chromopyrrolic acid; Streptomyces albus J1074
Issue Date
2009-03
Publisher
Bioorganic & medicinal chemistry letters
Citation
VOL 19, NO 6, 1581-1583
Abstract
Two ink genes, inkO and inkD, responsible for the earliest steps of K252a biosynthetic pathway, from Nonomurea longicantena JCM 11136 were heterologously coexpressed in Streptomyces albus J1074. The resultant strain accumulated compound that was purified by HPLC and studied by NMR. Coexpression of inkOD yielded chromopyrrolic acid, the key intermediate in an indolocarbazole biosynthesis.
URI
http://pubs.kist.re.kr/handle/201004/35571
ISSN
0960-894X
Appears in Collections:
KIST Publication > Article
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE