Synthesis of a new 4-(pyridin-3-yl)pyrimidine derivatives for anticancer activity

Title
Synthesis of a new 4-(pyridin-3-yl)pyrimidine derivatives for anticancer activity
Authors
정세진무스타파이소하
Keywords
Anticancer activity; 4-(pyridin-3-yl)pyrimidine derivatives; A375P melanoma cell; B-Raf
Issue Date
2009-03
Publisher
한국유화학회지; Journal of the Korean Oil Chemists Society
Citation
VOL 26, NO 1, 36-44
Abstract
This study is focused on the synthesis of urea and amide derivatives particularly, since the amide moiety is an essential binding group at the binding site. Urea derivatives 3-7 and 13-14 were obtained by reaction of 2-aminopyrimidines and other amines with diverse isocyanates in pyridine as a solvent under reflux. The urea derivatives were obtained in low yield because of the highly electron deficient nature of the amino group of the 2-aminopyrimidine. Amide derivatives 8-10 were obtained in moderate yields by reaction of compound 1 with aryl chloride derivatives. Also, Arylamine 11 was synthesized by Buchwald-Hartwig amination in moderate yields. Most of the compound did not show good activity against A374P melanoma cells, compared with Sorafenib as control compound.
URI
http://pubs.kist.re.kr/handle/201004/35616
ISSN
1225-9098
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KIST Publication > Article
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