Full metadata record

DC FieldValueLanguage
dc.contributor.author정세진-
dc.contributor.author무스타파-
dc.contributor.author이소하-
dc.date.accessioned2015-12-02T15:10:04Z-
dc.date.available2015-12-02T15:10:04Z-
dc.date.issued200903-
dc.identifier.citationVOL 26, NO 1, 36-44-
dc.identifier.issn1225-9098-
dc.identifier.other30319-
dc.identifier.urihttp://pubs.kist.re.kr/handle/201004/35616-
dc.description.abstractThis study is focused on the synthesis of urea and amide derivatives particularly, since the amide moiety is an essential binding group at the binding site. Urea derivatives 3-7 and 13-14 were obtained by reaction of 2-aminopyrimidines and other amines with diverse isocyanates in pyridine as a solvent under reflux. The urea derivatives were obtained in low yield because of the highly electron deficient nature of the amino group of the 2-aminopyrimidine. Amide derivatives 8-10 were obtained in moderate yields by reaction of compound 1 with aryl chloride derivatives. Also, Arylamine 11 was synthesized by Buchwald-Hartwig amination in moderate yields. Most of the compound did not show good activity against A374P melanoma cells, compared with Sorafenib as control compound.-
dc.publisher한국유화학회지-
dc.publisherJournal of the Korean Oil Chemists Society-
dc.subjectAnticancer activity-
dc.subject4-(pyridin-3-yl)pyrimidine derivatives-
dc.subjectA375P melanoma cell-
dc.subjectB-Raf-
dc.titleSynthesis of a new 4-(pyridin-3-yl)pyrimidine derivatives for anticancer activity-
dc.typeArticle-
Appears in Collections:
KIST Publication > Article
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE