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|dc.identifier.citation||VOL 26, NO 1, 36-44||-|
|dc.description.abstract||This study is focused on the synthesis of urea and amide derivatives particularly, since the amide moiety is an essential binding group at the binding site. Urea derivatives 3-7 and 13-14 were obtained by reaction of 2-aminopyrimidines and other amines with diverse isocyanates in pyridine as a solvent under reflux. The urea derivatives were obtained in low yield because of the highly electron deficient nature of the amino group of the 2-aminopyrimidine. Amide derivatives 8-10 were obtained in moderate yields by reaction of compound 1 with aryl chloride derivatives. Also, Arylamine 11 was synthesized by Buchwald-Hartwig amination in moderate yields. Most of the compound did not show good activity against A374P melanoma cells, compared with Sorafenib as control compound.||-|
|dc.publisher||Journal of the Korean Oil Chemists Society||-|
|dc.subject||A375P melanoma cell||-|
|dc.title||Synthesis of a new 4-(pyridin-3-yl)pyrimidine derivatives for anticancer activity||-|
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