Micro- and Nanocantilever Devices and Systems For Biomolecule Detection

Title
Micro- and Nanocantilever Devices and Systems For Biomolecule Detection
Authors
황교선이상명김상경이정훈김태송
Keywords
Miniaturization; Biosensors; Nanomechanics
Issue Date
2009-07
Publisher
Annual Review of Analytical Chemistry
Citation
VOL 2, 77-98
Abstract
Recent research trends in biosensing have been geared toward developing bioanalytical devices that are label free, small in size, and portable and that can operate in a rapid manner. The performance of these devices has been dramatically improved through the advent of new materials and micro-/ nanofabrication technologies. This is especially true for micro-/nanosized cantilever sensors, which undergo a change in mechanical properties upon the specific binding of biomolecules. In this review, we introduce the basic principles of cantilever biosensors in static and dynamic modes. We also summarize a range of approaches to cantilever design, fabrication, and instrumentation according to their applications. More specifically, we describe cantilever-based detections of proteins, DNA molecules, bacteria, and viruses and discuss current challenges related to the targets’ biophysical characteristics.
URI
http://pubs.kist.re.kr/handle/201004/35628
ISSN
1936-1327
Appears in Collections:
KIST Publication > Article
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