Anti-inflammatory Mechanism of Seaweeds in Murine Macrophage

Title
Anti-inflammatory Mechanism of Seaweeds in Murine Macrophage
Authors
판철호김은선엄병헌이재권
Keywords
Desmarestia viridis; Dictyopteris divaricata; Scytosiphon lomentaria; Ishige okamurae; inducible nitric oxide synthase (iNOS); interlukin-1β; cyclooxygenase (COX)-2; proinflammatory cytokine; anti-inflammation; 1κB
Issue Date
2009-06
Publisher
Food science and biotechnology
Citation
VOL 18, NO 3, 813-817
Abstract
The effect of 4 seaweed extracts (Desmarestia viridis, Dictyopteris divaricata, Scytosiphon lomentaria, and Ishigeokamurae) on pro-inflammatory mediators as well as nuclear factor (NF)-κB in the stimulated Raw 264.7 cells wasinvestigated. They reduced iNOS and interlukin (IL)-1β expressions at transcription level. Of those, 3 extracts (D. divaricata,I. okamurae, and S. lomentaria) inhibited the COX-2 expression at translation level. IκB-α degradation was inhibited by D.divaricata and S. lomentaria extracts. Therefore, we concluded that the extracts from D. divaricata and S. lomentaria couldinhibit the activation of murine macrophage through the blocking of NF-κB activation.
URI
http://pubs.kist.re.kr/handle/201004/35646
ISSN
1226-7708
Appears in Collections:
KIST Publication > Article
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE