Glionitrin A, an antibiotic-antitumor metabolite derived from competitive interaction between abandoned mine microbes
- Glionitrin A, an antibiotic-antitumor metabolite derived from competitive interaction between abandoned mine microbes
- 박현봉; 권학철; 이창호; 양현옥
- Co-Culture; Mine Microorganisms; Sphingomonas; Aspergillus; Novel Compound; anticancer; antibiotics; Glionitrin
- Issue Date
- Journal of natural products
- VOL 72, NO 2, 248-252
- The nutrient conditions present in abandoned coal mine drainages create an extreme environment where defensive and offensive microbial interactions could be critical for survival and fitness. Coculture of a mine drainage-derived Sphingomonas bacterial strain, KMK-001, and a mine drainage-derived Aspergillus fumigatus fungal strain, KMC-901, resulted in isolation of a new diketopiperazine disulfide, glionitrin A (1). Compound 1 was not detected in monoculture broths of KMK-001 or KMC-901. The structure of 1, a (3S,10aS) diketopiperazine disulfide containing a nitro aromatic ring, was based on analysis of MS, NMR, and circular dichroism spectra and confirmed by X-ray crystal data. Glionitrin A displayed significant antibiotic activity against a series of microbes including methicillin-resistant Staphylococcus aureus. An in Vitro MTT cytotoxicity assay revealed that 1 had potent submicromolar cytotoxic activity against four human cancer cell lines: HCT-116, A549, AGS, and DU145. The results provide further evidence that microbial coculture can produce novel biologically relevant molecules.
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