Inhibitory effect of chalcones and their derivatives from Glycyrrhiza inflata on protein tyrosine phosphatase 1B

Title
Inhibitory effect of chalcones and their derivatives from Glycyrrhiza inflata on protein tyrosine phosphatase 1B
Authors
윤구이우정김수남천승훈
Keywords
Glycyrrhiza inflata; Allyl retrochalcone; Licochalcone A; Semisynthetic; Protein tyrosine phosphatase 1B
Issue Date
2009-08
Publisher
Bioorganic & medicinal chemistry letters
Citation
VOL 19, NO 17, 5155-5157
Abstract
Compounds (1–6) isolated from the CH2Cl2 extract of Glycyrrhiza inflata and semisynthetic licochalcone A derivatives (7–14) were evaluated for their protein tyrosine phosphatase 1B (PTP1B) inhibitory activities. Licochalcones A (4) and E (6), each with an allyl group at position 5 in the B ring exhibited significant inhibitory effects. Licochalcone A derivative 7, the most potent among the series, had an IC50 value of 11.7 ± 2.0 μM, ca. twofold better than that of licochalcone A (4).
URI
http://pubs.kist.re.kr/handle/201004/35703
ISSN
0960-894X
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KIST Publication > Article
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