Enhanced Dermal Wound Neovascularization by Targeted Delivery of Endothelial Progenitor Cells using an RGD-g-PLLA Scaffold

Title
Enhanced Dermal Wound Neovascularization by Targeted Delivery of Endothelial Progenitor Cells using an RGD-g-PLLA Scaffold
Authors
김경리한동근박귀덕송선화김지연김정민기호윤이세원로청래전은석김덕경서원희
Keywords
Scaffold; EPC; RGD; Neovascularization; Angiogenesis; Endothelial cells; Stem cells; Wound healing
Issue Date
2009-08
Publisher
Biomaterials
Citation
VOL 30, NO 22, 3742-3748
Abstract
Endothelial progenitor cells (EPCs), endothelial precursors that promote neovascularization in ischemic tissues, have shown the limited vascular regeneration efficacy due to their poor homing into injured sites and low survival, so that a variety of biosynthetic scaffolds have been employed as cell delivery vehicles to overcome the current cell transplantation methods. However, few paralleled studies that directly compare the efficacy of EPCs seeded within synthetic scaffolds to that of EPCs delivered by the conventional transplantation techniques used for EPC therapies have been performed. To address these issues, RGD-g-PLLA biosynthetic scaffold was developed for the targeted EPC delivery and was found to successfully support the in vitro growth and endothelial functions of EPCs. This scaffold also appeared to be good as in vivo targeted delivery carriers of EPCs as it promoted vascular regeneration in a murine dermal wound models. Furthermore, direct comparison with the intradermal EPC injection revealed that the targeted delivery of EPCs by using the RGD-g-PLLA scaffold was superior to their conventional local injection method in terms of the localization and survival/retention of the transplanted EPCs, and their vascular repairing potential. These results suggest that the development of an effective stem cell delivery system may help to maximize the tissue-repairing efficacy with a limited number of stem cells, thereby resolving the limited clinical success of current stem cell therapies that have utilized simple cell injections or infusions.
URI
http://pubs.kist.re.kr/handle/201004/35706
ISSN
0142-9612
Appears in Collections:
KIST Publication > Article
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE