Total Synthesis and Structural Revision of (±)-Tricholomalides A and B

Title
Total Synthesis and Structural Revision of (±)-Tricholomalides A and B
Authors
Zhang Wang민선준Samuel J.Danishefsky
Keywords
Total Synthesis; neurodegenerative diseases
Issue Date
2009-08
Publisher
Journal of the American Chemical Society
Citation
VOL 131, NO 31, 10848-10849
Abstract
In summary, a concise synthesis of the neurotrophically active tricholomalides A and B has been accomplished, and the structures of these natural products have been reassigned. We are confident that an enantiopure synthesis of 1 and 2 is achievable, since substantially enantiopure 7 has been synthesized in our laboratory. The biological evaluations of the tricholomalides will be disclosed in due course.
URI
http://pubs.kist.re.kr/handle/201004/35713
ISSN
0002-7863
Appears in Collections:
KIST Publication > Article
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