Aminoquinoline Derivatives with Antiproliferative Activity against Melanoma Cell Line

Title
Aminoquinoline Derivatives with Antiproliferative Activity against Melanoma Cell Line
Authors
유경호남봉수안혜미이소하
Issue Date
2009-08
Publisher
42nd IUPAC Congress
Abstract
Melanoma is the most serious type of skin cancer as a malignant tumor of melanocytes. Metastatic melanoma can be fatal with the 5-year survival rate below 15% and median survival of about 6-8 months.1 Due to the development of metastatic disease which is highly resistant to conventional chemotherapeutics and radiation, the intensive research and effort into new drugs and treatments2 afforded merely the response rates of approximately 20% or less. We report here the synthesis of a novel series of aminoquinoline derivatives 1a-p based on the structural features of Sorafenib (Nexavar)3 (Figure 1) and their antiproliferative activities and selectivities against human melanoma cell line and fibroblast cell line.
URI
http://pubs.kist.re.kr/handle/201004/35715
Appears in Collections:
KIST Publication > Conference Paper
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