Hair metabolomics in biomarker discovery

Title
Hair metabolomics in biomarker discovery
Authors
최만호
Keywords
metabolomics; hair; steroid; biomarker
Issue Date
2009-08
Publisher
Asia Young Analytical Chemist Session
Abstract
The objective of hair metabolomics is to investigate alteration of lipoidal metabolites in hair samples obtained from patients with many diseases using mass spectrometry based analytical techniques. Due to the metabolic perturbation in hair reflects the conditions of diseases, the level of diverse lipoidal molecules were evaluated. In the present studies, metabolite profiling in combination with or without multivariate data analysis was therefore introduced to quantify changes in hair metabolic patterns for mining biomarkers in and evaluating drug efficacies in skin-appendage diseases (SAD). The hair samples were extracted with optimized conditions depends on the characteristics of analytes and analyzed by gas or liquid chromatography-mass spectrometry (GC-MS or LC-MS). Altered hair steroid levels could indicate SAD development as well as drug effects due to its direct action or stimulatory effect on local enzyme activity. This presentation will demonstrate that the described MS based hair metabolomics is potentially useful diagnostic tools and provide an effective means of biomarker ‘mining’.
URI
http://pubs.kist.re.kr/handle/201004/35719
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KIST Publication > Conference Paper
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