Injectable and Thermosensitive Poly(organophosphazene) Hydrogels for a 5-Fluorouracil Delivery

Title
Injectable and Thermosensitive Poly(organophosphazene) Hydrogels for a 5-Fluorouracil Delivery
Authors
이선미전창주허정윤송수창
Keywords
polyphosphazene; biodegradable; drug delivery system; thermosensitive hydrogels; injectable
Issue Date
2009-06
Publisher
Journal of applied polymer science
Citation
VOL 113, 3831-3839
Abstract
The drug solubility and its release profiles of an anticancer drug from an injectable thermosensitive poly(organophosphazene) hydrogel bearing hydrophobic L-isoleucine ethyl ester and hydrophilic a-amino-xmethoxy- poly(ethylene glycol) with and without hydrolysis- sensitive glycyl lactate ethyl ester or functional glycyl glycine have been investigated. 5-Fluorouracil (5-FU) was used as a model anticancer drug. The aqueous solutions of 5-FU incorporated poly(organophosphazenes) were an injectable fluid state at room temperature and formed a transparent gel at body temperature. The poly(organophosphazene) solution could enhance the solubility of 5- FU and its solubility (34.26 mg/mL) was increased up to 10-fold compared to that in phosphate-buffered saline (3.39 mg/mL, pH 7.4, 4 C). The in vitro drug release profiles from poly(organophosphazene) hydrogels were established in phosphate-buffered saline at pH 7.4 at 37 C and the release of 5-FU was significantly affected by the diffusion-controlled stage. The results suggest that the injectable and thermosensitive poly(organophosphazene) hydrogel is a potential carrier for 5-FU to increase its solubility, control a relatively sustained and localized release at target sites and thus decrease systemic side effects.
URI
http://pubs.kist.re.kr/handle/201004/35730
ISSN
0021-8995
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KIST Publication > Article
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