Nanofibrous scaffolds electrospun from elastomeric biodegradable poly(L-lactide-co-e-caprolactone) copolymer
- Nanofibrous scaffolds electrospun from elastomeric biodegradable poly(L-lactide-co-e-caprolactone) copolymer
- 정상원; Ajit K Moghe; Gerardo A Montero; 김수현; Martin W King
- Issue Date
- Biomedical materials.
- VOL 4, NO 1, 015019-1-015019-9
- Electrospinning has recently received much attention in biomedical applications, and has
shown great potential as a novel scaffold fabrication method for tissue engineering. The nano
scale diameter of the fibers produced and the structure of the web resemble certain
supramolecular features of extracellular matrix which is favorable for cell attachment, growth
and proliferation. There are various parameters that can alter the electrospinning process, and
varying one or more of these conditions will result in producing different nanofibrous webs.
So the aim of this study was to investigate the effect of material variables and process variables on the morphology of electrospun 50:50 poly(L-lactide-co-ε-caprolactone) (PLCL)
nanofibrous structures. The morphology of the nanofibers produced was strongly influenced
by parameters such as the flow rate of the polymer solution, the electrospinning voltage and
the solution concentration. The diameter was found to increase with solution concentration in
a direct linear relationship. Finally, it has been successfully demonstrated that by increasing
the rotation speed of the collector mandrel, the alignment of the fibers can be controlled in a
preferred direction. These findings contribute to determining the functional conditions to
electrospin this biodegradable elastomeric copolymer which has potential as a scaffold
material for vascular tissue engineering.
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