Nanofibrous scaffolds electrospun from elastomeric biodegradable poly(L-lactide-co-e-caprolactone) copolymer

Title
Nanofibrous scaffolds electrospun from elastomeric biodegradable poly(L-lactide-co-e-caprolactone) copolymer
Authors
정상원Ajit K MogheGerardo A Montero김수현Martin W King
Issue Date
2009-02
Publisher
Biomedical materials.
Citation
VOL 4, NO 1, 015019-1-015019-9
Abstract
Electrospinning has recently received much attention in biomedical applications, and has shown great potential as a novel scaffold fabrication method for tissue engineering. The nano scale diameter of the fibers produced and the structure of the web resemble certain supramolecular features of extracellular matrix which is favorable for cell attachment, growth and proliferation. There are various parameters that can alter the electrospinning process, and varying one or more of these conditions will result in producing different nanofibrous webs. So the aim of this study was to investigate the effect of material variables and process variables on the morphology of electrospun 50:50 poly(L-lactide-co-ε-caprolactone) (PLCL) nanofibrous structures. The morphology of the nanofibers produced was strongly influenced by parameters such as the flow rate of the polymer solution, the electrospinning voltage and the solution concentration. The diameter was found to increase with solution concentration in a direct linear relationship. Finally, it has been successfully demonstrated that by increasing the rotation speed of the collector mandrel, the alignment of the fibers can be controlled in a preferred direction. These findings contribute to determining the functional conditions to electrospin this biodegradable elastomeric copolymer which has potential as a scaffold material for vascular tissue engineering.
URI
http://pubs.kist.re.kr/handle/201004/35794
ISSN
1748-6041
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KIST Publication > Article
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