Transcriptomic configuration of Mouse Brain induced by adolescent exposure to 3,4-methylenedioxymethamphetamine

Title
Transcriptomic configuration of Mouse Brain induced by adolescent exposure to 3,4-methylenedioxymethamphetamine
Authors
은정우곽승준노지헌정광화김정규배현진사홍건류재천안영민민진혜박원상이정영이규식남석우
Keywords
Transcriptomic configuration; 3,4-methylenedioxymethamphetamine; MDMA; Neurotoxicity; Cerebral cortex; Molecular signature
Issue Date
2009-05
Publisher
Toxicology and applied pharmacology
Citation
VOL 237, NO 1, 91-101
Abstract
The amphetamine derivative (±)-3,4-methylenedioxymethamphetamine (MDMA or ecstasy) is a synthetic amphetamine analogue used recreationally to obtain an enhanced affiliative emotional response. MDMA is a potent monoaminergic neurotoxin with the potential to damage brain serotonin and/or dopamine neurons. As the majority of MDMA users are young adults, the risk that users may expose the fetus to MDMA is a concern. However, the majority of studies on MDMA have investigated the effects on adult animals. Here, we investigated whether long-term exposure to MDMA, especially in adolescence, could induce comprehensive transcriptional changes in mouse brain. Transcriptomic analysis of mouse brain regions demonstrated significant gene expression changes in the cerebral cortex. Supervised analysis identified 1028 genes that were chronically dysregulated by long-term exposure to MDMA in adolescent mice. Functional categories most represented by this MDMA characteristic signature are intracellular molecular signaling pathways of neurotoxicity, such as, the MAPK signaling pathway, the Wnt signaling pathway, neuroactive ligand–receptor interaction, long-term potentiation, and the long-term depression signaling pathway. Although these resultant large-scale molecular changes remain to be studied associated with functional brain damage caused by MDMA, our observations delineate the possible neurotoxic effects of MDMA on brain function, and have therapeutic implications concerning neuro-pathological conditions associated with MDMA abuse.
URI
http://pubs.kist.re.kr/handle/201004/35819
ISSN
0041-008X
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KIST Publication > Article
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