Mechanisms underlying methotrexate-induced pulmonary toxicity
- Title
- Mechanisms underlying methotrexate-induced pulmonary toxicity
- Authors
- 김연정; 송미; 류재천
- Keywords
- methotrexate; pulmonary toxicity; mechanism; p38 MAPK
- Issue Date
- 2009-07
- Publisher
- Expert Opinion on Drug Safety
- Citation
- VOL 8, NO 4, 451-458
- Abstract
- Methotrexate (MTX) has been widely used for the treatment of inflammatory diseases and rheumatoid arthritis, as well as a variety of tumors. However, MTX-induced pulmonary toxicity is a serious and unpredictable side effect of the therapy, which includes allergic, cytotoxic or immunologic reactions, and is a major clinical problem. Objective: To summarize the mechanisms of action involved in MTX-induced pulmonary toxicity. Methods: We reviewed the literature describing MTX-induced adverse pulmonary effects and the mechanisms of action underlying MTX-induced pulmonary toxicity. Conclusion: The mechanisms underlying MTX toxicity are complex. The clinical effects may be attributable to both the anti-inflammatory and immunosuppressive effects of MTX. The mechanisms causing the side effects of MTX include mutation of the genotype, inhibition of transport, MTX-polyglutamates and P-glycoprotein binding with MTX. The p38 MAPK-signaling pathway is especially associated with a pulmonary inflammatory response. These mechanisms can be applied to optimize drug treatment.
- URI
- http://pubs.kist.re.kr/handle/201004/35821
- ISSN
- 1474-0338
- Appears in Collections:
- KIST Publication > Article
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