Styryl-based compounds as potential in vivo imaging agents for b-amyloid plaques

Title
Styryl-based compounds as potential in vivo imaging agents for b-amyloid plaques
Authors
Qian LiJaeki MinYoung-Hoon AhnJoshua NammEun Min KimRowena Lui김혜연Yong JiHueizhi WuThomas WisniewskiYoung-Tae Chang
Keywords
Alzheimer's disease; amyloid plaques; blood-brain barrier; fluorescent probes; imaging agents
Issue Date
2007-09
Publisher
Chembiochem : a European journal of chemical biology
Citation
VOL 8, NO 14, 1679-1687
Abstract
A group of styryl-based neutral compounds has been synthesized in this study for potential use as in vivo imaging agents for β-amyloid plaques. Of 56 candidates, 14 compounds were found to label β-amyloid plaques well on Alzheimer's disease (AD) human brain sections in vitro. The binding affinity to β-amyloid fibrils was then determined by measuring the change in fluorescence intensity. Interestingly, we found that a class of quinaldine-styryl scaffold compounds displays specific binding to β-amyloid fibrils. A representative compound, STB-8, was used in ex vivo and in vivo imaging experiments on an AD transgenic mouse model and demonstrated excellent blood-brain barrier (BBB) permeability and specific staining of the AD β-amyloid plaques.
URI
http://pubs.kist.re.kr/handle/201004/35844
ISSN
1439-4227
Appears in Collections:
KIST Publication > Article
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