Styryl-based compounds as potential in vivo imaging agents for b-amyloid plaques
- Styryl-based compounds as potential in vivo imaging agents for b-amyloid plaques
- Qian Li; Jaeki Min; Young-Hoon Ahn; Joshua Namm; Eun Min Kim; Rowena Lui; 김혜연; Yong Ji; Hueizhi Wu; Thomas Wisniewski; Young-Tae Chang
- Alzheimer's disease; amyloid plaques; blood-brain barrier; fluorescent probes; imaging agents
- Issue Date
- Chembiochem : a European journal of chemical biology
- VOL 8, NO 14, 1679-1687
- A group of styryl-based neutral compounds has been synthesized in this study for potential use as in vivo imaging agents for β-amyloid plaques. Of 56 candidates, 14 compounds were found to label β-amyloid plaques well on Alzheimer's disease (AD) human brain sections in vitro. The binding affinity to β-amyloid fibrils was then determined by measuring the change in fluorescence intensity. Interestingly, we found that a class of quinaldine-styryl scaffold compounds displays specific binding to β-amyloid fibrils. A representative compound, STB-8, was used in ex vivo and in vivo imaging experiments on an AD transgenic mouse model and demonstrated excellent blood-brain barrier (BBB) permeability and specific staining of the AD β-amyloid plaques.
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