Negligible Effect of Ginkgo Biloba Extract on the Pharmacokinetics of Cilostazol
- Negligible Effect of Ginkgo Biloba Extract on the Pharmacokinetics of Cilostazol
- 정혜진; 김남선; 김은정; 김태곤; 류근호; 이봉용; 김동현; 진창배; 유혜현
- Ginkgo biloba extract; cilostazol; cytochrome P450; pharmacokinetic interaction; dogs
- Issue Date
- Biomolecules & Therapeutics
- VOL 17, NO 3, 311-317
- Ginkgo biloba (G. biloba) extract is a widely used phytomedicine for the oral treatment of
peripheral vascular disease. Cilostazol is a synthetic antiplatelet and vasodilating agent for the treatment of
intermittent claudication resulting from peripheral arterial disease. It is likely to use concomitantly G. biloba
extract and cilostazol for the treatment of peripheral arterial disease, which raises a concern of increasing
their adverse effects of herbal-drug interactions. To clarify any possible herbal-drug interaction between G.
biloba extract and cilostazol, the effect of the G. biloba extract on the pharmacokinetics of cilostazol was
investigated. As cilostazol is known to be eliminated mainly by cytochrome P450 (CYP)-mediated
metabolism, we investigated the effects of G. biloba extract on the human CYP enzyme activities and the
effect of G. biloba extract on the pharmacokinetics of cilostazol after co-administration of the two agents to
male beagle dogs. The G. biloba extract inhibited more or less CYP2C8, CYP2C9, and CYP2C19 enzyme
activities in the in vitro microsomal study with IC50 values of 30.8, 60.5, and 25.2 μg/ml, respectively. In the
pharmacokinetic study, co-administration with the G. biloba extract had no significant effect on the
pharmacokinetics of cilostazol in dogs, although CYP2C has been reported to be responsible for the
metabolism of cilostazol. In conclusion, these results suggest that there may not be a pharmacokinetic
interaction between G. biloba extract and cilostazol.
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