Structural insights into Staphylococcus aureus enoyl-ACP reductase (FabI), in complex with NADP and triclosan

Title
Structural insights into Staphylococcus aureus enoyl-ACP reductase (FabI), in complex with NADP and triclosan
Authors
아밋김은경황광연
Keywords
enoyl reductase; FabI; NADP; triclosan; structure
Issue Date
2010-02
Publisher
Proteins
Citation
VOL 78, NO 2, 480-486
Abstract
Staphylococcus aureus, a gram-positive bacterium, is responsible for the wound infections and staphylococcal scalded skin syndrome, a cutaneous reaction to a staphylococcal exotoxin that is absorbed into the bloodstream. The emergence of antibiotic-resistant pathogens is a serious health problem worldwide, and S. aureus has become resistant to many commonly used antibiotics such as penicillins. Because of the existence of methicillin-resistant S. aureus (MRSA), the bacterium is a popular source of target proteins for use in drug design.
URI
http://pubs.kist.re.kr/handle/201004/35888
ISSN
0887-3585
Appears in Collections:
KIST Publication > Article
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