Synthesis and In-vitro Activity of 4'-Modified Analogues of ddA as Potent Anti-HIV Agents
- Synthesis and In-vitro Activity of 4'-Modified Analogues of ddA as Potent Anti-HIV Agents
- 홍준희; 오창현
- Antiviral agents; Deoxythreosyl C-Nucleoside; Ozonolysis; Phosphorylation
- Issue Date
- Archiv der Pharmazie
- VOL 342, NO 10, 600-604
- This paper reports the synthesis of novel 4-hydrophobic pocket deoxythreosyl C-nucleosides. The key threose-like intermediates 9 and 14 were constructed from acyclic ketone derivatives, respectively. The antiviral activities of the synthesized compounds against the HIV-1, HSV-1, HSV-2, and HCMV viruses were evaluated. The 9-deaza-adenine derivatives 10 and 20 showed good anti-HIV activity without exhibiting significant cytotoxicity.
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