Effect of P-glycoprotein on the tissue distribution of DHP107, oral paclitaxel formulation

Title
Effect of P-glycoprotein on the tissue distribution of DHP107, oral paclitaxel formulation
Authors
홍정완정혜진이인현곽영학박영택성하진정혜선
Keywords
tissue distribution; paclitaxel; oral formulation; P-glycoprotein; dispersion
Issue Date
2009-07
Publisher
Controlled Release Society
Abstract
The purpose of this study was to show the effect of pglycoprotein (P-gp) on the tissue distribution of paclitaxel after peroral administration of DHP107. The paclitaxel formulation comprising monoglyceride, triglyceride and tween 80 was administered orally to female FVB and FVB-mdr1a(-/-) mice. After the administration, the paclitaxel concentrations of the most organs is about 3 ~ 10-fold higher in mdr1a(-/-) mice than in wild type mice except for tissues in the gastrointestinal (GI) tract.
URI
http://pubs.kist.re.kr/handle/201004/36023
Appears in Collections:
KIST Publication > Conference Paper
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