Evaluation of the anti-tumor effects of paclitaxel-encapsulated pH-sensitive micelles

Title
Evaluation of the anti-tumor effects of paclitaxel-encapsulated pH-sensitive micelles
Authors
한종권김민상이두성김유신박랑운김광명권익찬
Keywords
paclitaxel; pH sensitive; micelle
Issue Date
2009-02
Publisher
Macromolecular research
Citation
VOL 17, NO 2, 99-103
Abstract
We evaluated the efficacy of pH-sensitive micelles, formed by methoxy poly(ethylene glycol)-b-poly(β-amino ester) (PEG-PAE), as carriers for paclitaxel (PTX), a drug currently used to treat various cancers. PTX was successful encapsulated by a film hydration method. Micelles encapsulated more than 70% of the PTX and the size of the PTX-encapsulated micelles (PTX-PM) was less than 150 nm. In vitro experiments indicated that the micelles were unstable below pH 6.5. After encapsulation of PTX within the micelles, dynamic light scattering (DLS) studies indicated that low pH had a similar demicellization effect. An in vitro release study indicated that PTX was slowly released at pH 7.4 (normal body conditions) but rapidly released under weakly acidic conditions (pH 6.0). We demonstrated the safety of micelles from in vitro cytotoxicity tests on HeLa cells and the in vivo anti-tumor activity of PTX-PM in B16F10 tumor-bearing mice. We concluded that these pH-sensitive micelles have potential as carriers for anti-cancer drugs.
URI
http://pubs.kist.re.kr/handle/201004/36102
ISSN
1598-5032
Appears in Collections:
KIST Publication > Article
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE