Particle-size Optimization for a Polymer coated Silica Gel in SMB Chromatography for Amino Acid Separation
- Particle-size Optimization for a Polymer coated Silica Gel in SMB Chromatography for Amino Acid Separation
- Se-Hee Jo; Qiao Han; 서영웅; Jin-Bok Ryu; Sung Chul Yi; 이기봉; 문성용
- Detailed model; Particle size optimization; Polymer coated silica gel; Pressure drop; Productivity; SMB chromatography
- Issue Date
- Journal of liquid chromatography & related technologies
- VOL 32, 2822-2838
- The performance of silica gel as an adsorbent for a chromatographic
separation has been recently improved by a special surface processing, in which high
purity silica was prepared and then coated with silicone polymer. The superiority of
such a polymer coated silica gel over conventional silica gels has been demonstrated
previously. In this study, the polymer coated silica gel was applied to a simulated
moving bed (SMB) chromatography for amino acid separation. Since the productivity
of SMB is largely affected by the size of adsorbent particle, the determination
of an optimal particle size for the polymer coated (P-C) silica gel is of importance.
Thus, a systematic method of particle size optimization in the SMB for amino acid
separation was developed. Based on the developed method, the optimal P-C silica
size was determined for the SMBs with different pressure ratings. The results
showed that the optimal P-C silica size occurred at the boundary between the pressure
limiting and the mass transfer limiting regions. More importantly, the optimal
P-C silica size was found to become smaller as the SMB with a higher pressure rating
was employed. The results of this study can play an important role in tailoring the
P-C silica gel to the SMB process for amino acid separation.
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