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dc.contributor.author노지헌-
dc.contributor.author송재희-
dc.contributor.author은정우-
dc.contributor.author김정규-
dc.contributor.author정광화-
dc.contributor.author배현진-
dc.contributor.authorHong Jian Xie-
dc.contributor.author류재천-
dc.contributor.author안영민-
dc.contributor.author위성준-
dc.contributor.author박원상-
dc.contributor.author이정용-
dc.contributor.author남석우-
dc.date.accessioned2015-12-02T15:14:37Z-
dc.date.available2015-12-02T15:14:37Z-
dc.date.issued200908-
dc.identifier.citationVOL 24, NO 2, 205-226-
dc.identifier.issn1107-3756-
dc.identifier.other31047-
dc.identifier.urihttp://pubs.kist.re.kr/handle/201004/36275-
dc.description.abstractHistone deacetylase (HDAC) inhibitors are emerging as an exciting new class of potential anti-cancer agents for the treatment of solid and hematological malignancies. However, the best characterized HDAC function concerns the control of gene expression via the regulation of transcription activation or repression. To understand the genome-wide effects of HDAC inhibition on gene regulation, we performed serial gene expression analyses from 0 to 48 h after treating MDAMB- 435, a melanoma-derived highly metastatic tumor cell line, with Apicidin, a HDAC inhibitor. Combined-transcriptomic analysis of large-scale molecular changes induced by Apicidin resulted in the identification of 631 outlier genes that were continuously up- or down-regulated during the 48 h study period. When the 631 outlier genes were mapped to known biological processes, cell-cycle suppression emerged as the function most elicited by Apicidin. In addition comprehensive negative cell-cycle regulation by Apicidin was dissected using gene expression data and validated by Western blot analysis. We suggest the 631 outlier genes as a characteristic molecular signature for Apicidin, and propose concurrent transcriptional suppression of major components of cell-cycle regulatory circuit as potent anti-tumor mechanism of Apicidin. Genetic elements identified during this study also provide the possibility of novel therapeutic interventions in tumor metastasis.-
dc.publisherInternational journal of molecular medicine-
dc.subjectcell-cycle suppression-
dc.subjectApicidin-
dc.subjectMDA-MB-435 human melanoma cells-
dc.subjectHDAC inhibitor-
dc.subjectDNA microarray-
dc.titleSystemic cell-cycle suppression by Apicidin, a histone deacetylase inhibitor, in MDA-MB-435 cells-
dc.typeArticle-
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