Development of Anti-Cancer Lead-Compounds from Theopederin Derivatives
- Development of Anti-Cancer Lead-Compounds from Theopederin Derivatives
- 심진희; 안홍열; 김동수; 조영애; 함정엽
- Anti-Cancer; Theopederin; Marine Natural Product
- Issue Date
- 2009강원지부 대한화학회
- Theopederin and its derivatives such as mycalamides, onnamides, isolated from marine sponge, have been reported to exhibit potent antiviral and antitumor properties due to their ability to arrest protein synthesis. Among them theopederin is polyketide of pederin family, isolated from sponge of the genus Theonella sp. in 1992 by Matsunaga group. Twelve isoforms known to exist (A-L), which compounds possess strong antitumor and antiviral activities, and some members display potencies at subnanomolar concentrations in cells as a consequence of protein synthesis inhibition. The unique chemical structures of them have provided motivation for the development of synthetic strategies toward these marine natural products. As a part of an ongoing anti-cancer drug discovery program, we are developing a facile synthetic method for preparation of theopederin E and its derivatives which are substituted with various aryl moieties. Herein, we describe the synthetic method for the preparation of natural and unnatural theopederin derivatives.
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