Development of Anti-Cancer Lead-Compounds from Theopederin Derivatives

Title
Development of Anti-Cancer Lead-Compounds from Theopederin Derivatives
Authors
심진희안홍열김동수조영애함정엽
Keywords
Anti-Cancer; Theopederin; Marine Natural Product
Issue Date
2009-10
Publisher
2009강원지부 대한화학회
Abstract
Theopederin and its derivatives such as mycalamides, onnamides, isolated from marine sponge, have been reported to exhibit potent antiviral and antitumor properties due to their ability to arrest protein synthesis. Among them theopederin is polyketide of pederin family, isolated from sponge of the genus Theonella sp. in 1992 by Matsunaga group. Twelve isoforms known to exist (A-L), which compounds possess strong antitumor and antiviral activities, and some members display potencies at subnanomolar concentrations in cells as a consequence of protein synthesis inhibition. The unique chemical structures of them have provided motivation for the development of synthetic strategies toward these marine natural products. As a part of an ongoing anti-cancer drug discovery program, we are developing a facile synthetic method for preparation of theopederin E and its derivatives which are substituted with various aryl moieties. Herein, we describe the synthetic method for the preparation of natural and unnatural theopederin derivatives.
URI
http://pubs.kist.re.kr/handle/201004/36404
Appears in Collections:
KIST Publication > Conference Paper
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