Total Synthesis of Theopederin E and Its Derivatives

Title
Total Synthesis of Theopederin E and Its Derivatives
Authors
심진희안홍열김동수조영애함정엽
Keywords
Theopederin; Marine Natural Product; Anti-Cancer
Issue Date
2009-09
Publisher
2009 CMDD Symposium on Marine Natural Products and Drug Discovery
Abstract
Theopederin and its derivatives such as Mycalamides, onnamides, isolated from marine sponge, have been reported to exhibit potent antiviral and antitumor properties due to their ability to arrest protein synthesis. The unique chemical structures of them have provided motivation for the development of synthetic strategies toward these marine natural products. As a part of an ongoing anti-cancer drug discovery program, we are developing a facile synthetic method for preparation of theopederin E and its derivatives which are substituted with various aryl moieties. Herein, we describe the synthesis of yhe cyclic alcohol 1 as a key intermidiate for preparation of theopederin E and its various reactions such as oxidation, Wittig, and Suzuki-Miyaura cross-coupling reaction.
URI
http://pubs.kist.re.kr/handle/201004/36405
Appears in Collections:
KIST Publication > Conference Paper
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