Membrane-Delimited Coupling of TRPV1 and mGluR5 on Presynaptic Terminals of Nociceptive Neurons
- Membrane-Delimited Coupling of TRPV1 and mGluR5 on Presynaptic Terminals of Nociceptive Neurons
- 김용호; 박철규; 백승근; 이창준; 황세진; 배용철; 나흥식; 김중수; 정승준; 오석배
- TRPV1; mGluR5; Nociceptive Neuron; presynaptic terminal
- Issue Date
- The Journal of neuroscience : the official journal of the Society for Neuroscience
- VOL 29, NO 32, 10000-10009
- Transient receptor potential vanilloid subtype 1 (TRPV1) and metabotropic glutamate receptor 5 (mGluR5) located on peripheral
sensory terminals have been shown to play critical roles in the transduction and modulation of pain sensation. To date, however, very
little is known regarding the significance of functional expression of mGluR5 and TRPV1 on the central terminals of sensory neurons in
the dorsal horn of the spinal cord. Here we show that TRPV1 on central presynaptic terminals is coupled to mGluR5 in a membranedelimited
manner, thereby contributing to the modulation of nociceptive synaptic transmission in the substantia gelatinosa neurons of
the spinal cord. Further, our results demonstrate that TRPV1 is involved in the pain behaviors induced by spinal mGluR5 activation, and
diacylglycerol produced by the activation of mGluR5 mediates functional coupling of mGluR5 and TRPV1 on the presynaptic terminals.
Thus, mGluR5–TRPV1 coupling on the central presynaptic terminals of nociceptive neurons may be an important mechanism underlying
central sensitization under pathological pain conditions.
- Appears in Collections:
- KIST Publication > Article
- Files in This Item:
There are no files associated with this item.
- RIS (EndNote)
- XLS (Excel)
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.