Evaluation of a serum marker endorepellin LG3 fragment combined with mammography for breast cancer diagnosis
- Evaluation of a serum marker endorepellin LG3 fragment combined with mammography for breast cancer diagnosis
- 양은경; 한기철; 이종원; 노동영; 이철주; 유명희
- Issue Date
- Next Generation Diagnostics Summit
- Mammography has served as a screening method for early detection of breast cancer, but its effectiveness in women under age 50 remains controversial. Among various modalities currently available, circulating biomarkers are expected to improve early diagnosis and patient selection, and to provide a way to monitor response to therapy. Previously, a proteomic approach was employed to identify endorepellin LG3 fragment as a differentially expressed anti-angiogenic factor from comparative secretome analysis between human non-tumor and malignant breast cell lines. Here, we have examined association of ERLG3 fragment levels with various clinicopathologic variables, with a particularly focus on mammographic breast density. Our data support that detection of serum levels of ERLG3 fragment could be successfully combined with screening mammography as a novel screening tool. (This work is supported by the Functional Proteomics Center)
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