Dye-Condensed Biopolymeric Hybrids: Chromophoric Aggregation and Self-Assembly toward Fluorescent Bionanoparticles for Near Infrared Bioimaging
- Dye-Condensed Biopolymeric Hybrids: Chromophoric Aggregation and Self-Assembly toward Fluorescent Bionanoparticles for Near Infrared Bioimaging
- 임창근; 김세훈; 권익찬; 안철희; 박수영
- Issue Date
- Chemistry of materials
- VOL 21, NO 24, 5819-5825
- Novel fluorescent bionanoparticles (GC3CNx) were prepared by self-assembly of biopolymeric
amphiphiles that are composed of hydrophilic glycol chitosan (GC) as a biopolymeric backbone and
a dipolar tricyanostilbene derivative (3CN) as a densely conjugated hydrophobic pendant. In the
molecular design of 3CN, a dipolar electronic structure was introduced to spectrally shift the
aggregation-induced enhanced fluorescence of the R-cyanostilbene skeleton toward the near-infrared
(NIR) useful for bioimaging. It has been found that the fluorescence of GC3CNx nanoparticles is
red-shifted and intensified by increasing the 3CN content in the biopolymeric amphiphile. By cellular
and in vivo imaging experiments, we demonstrate that GC3CNx nanoparticles have great potential
for NIR bioimaging, with attractive properties including enhanced fluorescence signal, efficient
cellular uptake, and better spectral coincidence with the in vivo transparent window.
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