Pharmacokinetics of ipriflavone and its two metabolites, M1 and M5, after the intravenous and oral administration of ipriflavone to rat model of diabetes mellitus induced by streptozotocin

Title
Pharmacokinetics of ipriflavone and its two metabolites, M1 and M5, after the intravenous and oral administration of ipriflavone to rat model of diabetes mellitus induced by streptozotocin
Authors
이대영정혜진최영희이은지김소희이인철이명걸
Keywords
ipriflavone; diabetes mellitus; pharmacokinetics; CYP1A and 2C11; rats; M1 and M5; streptozotocin; CYP1A subfamily and 2C11
Issue Date
2009-12
Publisher
European journal of pharmaceutical sciences
Citation
VOL 38, NO 5, 465-471
Abstract
Ipriflavone was reported to be primarily metabolized via hepatic cytochrome P450 (CYP) 1A1/2 and 2C11 in male Sprague–Dawley rats. The protein expression and/ormRNAlevels of hepatic CYP1A subfamily and 2C11 was reported to be increased and decreased, respectively, in diabetic rats induced by streptozotocin (DMIS rats). Thus, the pharmacokinetic parameters of ipriflavone and its two metabolites, M1 and M5, were compared after the i.v. (20 mg/kg) and p.o. (200 mg/kg) administration of ipriflavone to control and DMIS rats. After both i.v. and p.o. administration of ipriflavone to DMIS rats, the AUCs of ipriflavone were significantly smaller (by 31.7% and 34.2% for i.v. and p.o. administration, respectively) than controls. The faster Clnr (smaller AUC) of i.v. ipriflavone could have been due to the faster hepatic Clint (because of an increase in the protein expression and/or mRNA level of hepatic CYP1A subfamily) and the faster hepatic blood flow rate than controls. The smaller AUC of p.o. ipriflavone in DMIS rats could have mainly been due to the faster intestinal Clint (because of an increase in the intestinal CYP1A subfamily) than controls.
URI
http://pubs.kist.re.kr/handle/201004/36746
ISSN
0928-0987
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KIST Publication > Article
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