Full metadata record

DC FieldValueLanguage
dc.contributor.author이대영-
dc.contributor.author정혜진-
dc.contributor.author최영희-
dc.contributor.author이은지-
dc.contributor.author김소희-
dc.contributor.author이인철-
dc.contributor.author이명걸-
dc.date.accessioned2015-12-02T15:18:19Z-
dc.date.available2015-12-02T15:18:19Z-
dc.date.issued200912-
dc.identifier.citationVOL 38, NO 5, 465-471-
dc.identifier.issn0928-0987-
dc.identifier.other31564-
dc.identifier.urihttp://pubs.kist.re.kr/handle/201004/36746-
dc.description.abstractIpriflavone was reported to be primarily metabolized via hepatic cytochrome P450 (CYP) 1A1/2 and 2C11 in male Sprague–Dawley rats. The protein expression and/ormRNAlevels of hepatic CYP1A subfamily and 2C11 was reported to be increased and decreased, respectively, in diabetic rats induced by streptozotocin (DMIS rats). Thus, the pharmacokinetic parameters of ipriflavone and its two metabolites, M1 and M5, were compared after the i.v. (20 mg/kg) and p.o. (200 mg/kg) administration of ipriflavone to control and DMIS rats. After both i.v. and p.o. administration of ipriflavone to DMIS rats, the AUCs of ipriflavone were significantly smaller (by 31.7% and 34.2% for i.v. and p.o. administration, respectively) than controls. The faster Clnr (smaller AUC) of i.v. ipriflavone could have been due to the faster hepatic Clint (because of an increase in the protein expression and/or mRNA level of hepatic CYP1A subfamily) and the faster hepatic blood flow rate than controls. The smaller AUC of p.o. ipriflavone in DMIS rats could have mainly been due to the faster intestinal Clint (because of an increase in the intestinal CYP1A subfamily) than controls.-
dc.publisherEuropean journal of pharmaceutical sciences-
dc.subjectipriflavone-
dc.subjectdiabetes mellitus-
dc.subjectpharmacokinetics-
dc.subjectCYP1A and 2C11-
dc.subjectrats-
dc.subjectM1 and M5-
dc.subjectstreptozotocin-
dc.subjectCYP1A subfamily and 2C11-
dc.titlePharmacokinetics of ipriflavone and its two metabolites, M1 and M5, after the intravenous and oral administration of ipriflavone to rat model of diabetes mellitus induced by streptozotocin-
dc.typeArticle-
Appears in Collections:
KIST Publication > Article
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE