Inhibitory Effects of 3,5-O-Dicaffeoyl-epi-quinic Acid from Gymnaster koraiensis on AKR1B10

Title
Inhibitory Effects of 3,5-O-Dicaffeoyl-epi-quinic Acid from Gymnaster koraiensis on AKR1B10
Authors
이주영송대근이은하정상훈노주원차광현판철호
Keywords
AKR1B10; aldose reductase-like; anticancer; 3,5-DCQA; 3,5-O-dicaffeoyl-epi-quinic acid; Gymnaster koraiensis
Issue Date
2009-12
Publisher
한국응용생명화학회지; JOURNAL OF THE KOREAN SOCIETY FOR APPLIED BIOLOGICAL CHEMISTRY
Citation
VOL 52, NO 6, 731-734
Abstract
AKR1B10 is a human NADPH-dependent aldo-keto reductase family 1 B10, which has been considered as a potential cancer therapeutic target. 3,5-O-Dicaffeoyl-epi-quinic acid (3,5-DCQA) was isolated from ethyl acetate fraction of Gymnaster koraiensis (Nakai) Kitam as an AKR1B10 inhibitor. 3,5-DCQA inhibited the activity of recombinant human AKR1B10 (rhAKR1B10) with its IC50 value of 1.2 μM and its inhibition mode was uncompetitive from enzyme kinetic analysis.
URI
http://pubs.kist.re.kr/handle/201004/36915
ISSN
1738-2203
Appears in Collections:
KIST Publication > Article
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE