Antioxidant and Aldo-keto reductase family 1 B10 Inhibition Activities of Korean Local Plant Extracts

Title
Antioxidant and Aldo-keto reductase family 1 B10 Inhibition Activities of Korean Local Plant Extracts
Authors
판철호이주영송대근김종환안수용배덕성김영훈이재권
Keywords
ABTS radical scavenging activity; Aldo-keto reductase family 1 B10; aldose reductase-like 1; antioxidant; anti-cancer
Issue Date
2009-12
Publisher
Journal of applied biological chemistry.
Citation
VOL 52, NO 4, 216-220
Abstract
Aldo-keto reductase family 1 B10 (AKR1B10) has been considered as a potential cancer therapeutic target. Ethanol extracts prepared from 82 Korean local plants were examined for their antioxidant activity and inhibitory effects on recombinant human AKR1B10 (rhAKR1B10) in vitro. 21 extracts showed more than 80% of ABTS radical scavenging activity at 100 μg/mL and 11 extracts inhibited more than 50% of rhAKR1B10 activity at 10 μg/mL. Especially, 9 extracts showed potent inhibition on rhAKR1B10 activity compared with positive control tetramethylene glutaric acid.
URI
http://pubs.kist.re.kr/handle/201004/36934
ISSN
1976-0442
Appears in Collections:
KIST Publication > Article
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