Hepatoprotective and Antioxidant Capacities of Paecilomyces japonica and Cordyceps sinensis in Rats with CCl4-Induced Hepatic Injury

Title
Hepatoprotective and Antioxidant Capacities of Paecilomyces japonica and Cordyceps sinensis in Rats with CCl4-Induced Hepatic Injury
Authors
정상훈이연실임순성김영식이상현신국현
Keywords
antioxidant enzymes; DPPH; fungus; TBA-reactant assay; transaminase
Issue Date
2009-12
Publisher
원예과학기술지
Citation
VOL 27, NO 4, 668-672
Abstract
Antioxidant and hepatoprotective activities of the fruiting bodies of Paecilomyces japonica (PJ) grown on silk-worm larvae and of Cordyceps sinensis (CS), a wild form of Cordyceps, were investigated. The 70% ethanol extracts of both fungi, PJ and CS, were found to exhibit free radical scavenging effects on 1,1-diphenyl- 2-picrylhydrazyl (DPPH). The inhibitory potency of PJ (IC50 = 163 μg・mL-1) was approximately 4.5 folds that of CS (IC50 = 731 μg・mL-1). They exhibited a moderate decrease in serum transaminase activities elevated by hepatic damage induced by carbon tetrachloride (CCl4)-intoxication in rats. Both fungal extracts also exhibited not only significant increases in hepatic superoxide dismutase (SOD) and catalase at a dose of 300 mg・kg-1 in CCl4-intoxicated rats, but also a significant decrease in malondialdehyde (MDA) production in a thiobarbituric acid (TBA) reactant assay in rats. Although no significant glutathione peroxidase (GSH-px) activity was detected, SOD and catalase elevations were obtained.
URI
http://pubs.kist.re.kr/handle/201004/36994
ISSN
1226-8763
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KIST Publication > Article
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