Hepatoprotective and Antioxidant Capacities of Paecilomyces japonica and Cordyceps sinensis in Rats with CCl4-Induced Hepatic Injury
- Hepatoprotective and Antioxidant Capacities of Paecilomyces japonica and Cordyceps sinensis in Rats with CCl4-Induced Hepatic Injury
- 정상훈; 이연실; 임순성; 김영식; 이상현; 신국현
- antioxidant enzymes; DPPH; fungus; TBA-reactant assay; transaminase
- Issue Date
- VOL 27, NO 4, 668-672
- Antioxidant and hepatoprotective activities of the fruiting bodies of Paecilomyces japonica (PJ) grown
on silk-worm larvae and of Cordyceps sinensis (CS), a wild form of Cordyceps, were investigated. The 70%
ethanol extracts of both fungi, PJ and CS, were found to exhibit free radical scavenging effects on 1,1-diphenyl-
2-picrylhydrazyl (DPPH). The inhibitory potency of PJ (IC50 = 163 μg･mL-1) was approximately 4.5 folds
that of CS (IC50 = 731 μg･mL-1). They exhibited a moderate decrease in serum transaminase activities elevated
by hepatic damage induced by carbon tetrachloride (CCl4)-intoxication in rats. Both fungal extracts also exhibited
not only significant increases in hepatic superoxide dismutase (SOD) and catalase at a dose of 300 mg･kg-1
in CCl4-intoxicated rats, but also a significant decrease in malondialdehyde (MDA) production in a thiobarbituric
acid (TBA) reactant assay in rats. Although no significant glutathione peroxidase (GSH-px) activity was detected,
SOD and catalase elevations were obtained.
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