Synthesis of pyrrolo[2,3-d]pyrimidine derivatives and their antiproliferative activity against melanoma cell line

Title
Synthesis of pyrrolo[2,3-d]pyrimidine derivatives and their antiproliferative activity against melanoma cell line
Authors
정명호김환최원경Mohammed I. El-Gamal박진헌유경호심태보이소하백대진하정미조정혁오창현
Keywords
Pyrrolo[2,3-d]pyrimidine; A375; HS 27; Antiproliferative activity; Melanoma
Issue Date
2009-12
Publisher
Bioorganic & medicinal chemistry letters
Citation
VOL 19, NO 23, 6538-6543
Abstract
Synthesis of a new series of diarylureas and amides having pyrrolo[2,3-d]pyrimidine scaffold is described. Their in vitro antiproliferative activities against A375 human melanoma cell line and HS 27 fibroblast cell line were tested and the effect of substituents on pyrrolo[2,3-d]pyrimidine was investigated. The newly synthesized compounds, except N-acetyl derivatives (Id, Ie, and Im), generally showed superior or similar activity against A375 to Sorafenib. Among all of these derivatives, compounds Iq and Ir having imidazole and morpholine moieties, respectively, showed the most potent antiproliferative activity against A375.
URI
http://pubs.kist.re.kr/handle/201004/37019
ISSN
0960-894X
Appears in Collections:
KIST Publication > Article
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