Multifunctional Nanoparticles for Molecular Imaging
- Multifunctional Nanoparticles for Molecular Imaging
- 강은아; 김광명; 권익찬
- Bioimaging; Multimodality; Nanoparticles; Activatable; Targeting; Biodistribution
- Issue Date
- 대한의사협회지; Journal of the Korean Medical Association.
- VOL 52, NO 2, 125-134
- Molecular imaging is a bioimaging that can detect biochemically and genetically relevant
events in molecular level in cells and tissues via quantitative imaging signal. Molecular
imaging provides potential advantages to examine early diagnosis of specific diseases, to screen
new candidates of a drug, to monitor therapeutic effects in real time, and to communicate with
both diagnosis and therapeutics. These diverse advantages of molecular imaging can be allowed
by development of nanoplatform technology. The nanoplatform-based probes for molecular
imaging is widely investigated to grant multimodal molecular imaging and drug delivery together
with medical imagings, which includes the issues of biocompatibility, targeting moiety, proteasespecific
peptide substrate, quenching/dequenching system etc. In this paper, nanoplatformbased
probes are reviewed in aspects of cancer targeting for diagnosis and therapy and
multimodal molecular imaging with inorganic/organic hybrid nanoparticles.
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