Effect of Licochalcone A on the Production of Cytokines in LPS-Activated RAW264.7 Macrophage Cells

Title
Effect of Licochalcone A on the Production of Cytokines in LPS-Activated RAW264.7 Macrophage Cells
Authors
이기세이성호조영창윤구천승훈강복윤
Keywords
licochalcone A; macrophage; inflammation; cytokines
Issue Date
2009-12
Publisher
약학회지
Citation
VOL 53, NO 6, 321-327
Abstract
Licochalcone A is a chalcone isolated from the roots of Glycyrrhiza inflate. In this study, we examined the effects of licochalonce A on the production of cytokines in LPS-activated macrophages. Licochalcone A inhibited the secretion of proinflammatory cytokines such as IL-1β, IL-6, and TNF-α. The reduced secretion of proinflammatory cytokines is related to the differences in the mRNA expression of IL-1β, IL-6, and TNF-α. Moreover, licochalcone A inhibited the mRNA expression of IL-12p40, IL-18, and IL-23p19. To investigate its mechanism, we performed gel shift assay. Licochalcone A reduced nuclear NF-κB binding activity in LPS-activated RAW264.7 cells. Taken together, these results suggest that licochalcone A has anti-inflammatory effects in LPS-activated macrophages and its mechanism could be through the down-regulation of binding to the κB site.
URI
http://pubs.kist.re.kr/handle/201004/37058
ISSN
0377-9556
Appears in Collections:
KIST Publication > Article
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE