Effect of Licochalcone A on the Production of Cytokines in LPS-Activated RAW264.7 Macrophage Cells
- Effect of Licochalcone A on the Production of Cytokines in LPS-Activated RAW264.7 Macrophage Cells
- 이기세; 이성호; 조영창; 윤구; 천승훈; 강복윤
- licochalcone A; macrophage; inflammation; cytokines
- Issue Date
- VOL 53, NO 6, 321-327
- Licochalcone A is a chalcone isolated from the roots of Glycyrrhiza inflate. In this study, we examined the
effects of licochalonce A on the production of cytokines in LPS-activated macrophages. Licochalcone A inhibited the secretion
of proinflammatory cytokines such as IL-1β, IL-6, and TNF-α. The reduced secretion of proinflammatory cytokines is
related to the differences in the mRNA expression of IL-1β, IL-6, and TNF-α. Moreover, licochalcone A inhibited the mRNA
expression of IL-12p40, IL-18, and IL-23p19. To investigate its mechanism, we performed gel shift assay. Licochalcone A
reduced nuclear NF-κB binding activity in LPS-activated RAW264.7 cells. Taken together, these results suggest that licochalcone
A has anti-inflammatory effects in LPS-activated macrophages and its mechanism could be through the down-regulation
of binding to the κB site.
- Appears in Collections:
- KIST Publication > Article
- Files in This Item:
There are no files associated with this item.
- RIS (EndNote)
- XLS (Excel)
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.