Tripodal amphiphiles tunable for self-assembly to polymersomes

Title
Tripodal amphiphiles tunable for self-assembly to polymersomes
Authors
전용주박민경Vithal B. Jadhav송주희채송화이화정박경수정병문최진호손연수
Keywords
Polymersome; Micelle; Amphiphile; Cyclotriphosphazene; Oligopeptide
Issue Date
2010-02
Publisher
Journal of controlled release
Citation
VOL 142, NO 1, 132-137
Abstract
Cyclotriphosphazenes grafted with equimolar amounts of a hydrophilic polyethylene glycol and a hydrophobic oligopeptide in cis-nongeminal way form a new class of tripodal amphiphiles allowing both intra- and intermolecular hydrophobic interactions that differ from linear block copolymer amphiphiles. It has been found in this study that the tripodal amphiphiles can be tuned for self-assembly from micelles to bilayered polymersomes by controlling the hydrophobicity of the oligopeptide grafted. For instance, the tripodal amphiphiles with an intermediate hydrophobicity (0 < log P < 1) (P = [solute]n-octanol / [solute]water) reassemble from initially formed micelles into polymersomes, whereas the trimers bearing highly hydrophobic oligopeptides (log P > 1) remain as stable micelles in aqueous solution. These biodegradable polymersomes exhibit outstanding physicochemical properties required for practical drug delivery and other biomedical applications. In particular, the cyclic phosphazene trimer platinated with a hydrophobic cis-bis(cyclohexylamine)Pt-moiety forms very stable polymersomes with excellent tumor selectivity by EPR effect and seems to be a promising candidate for preclinical studies.
URI
http://pubs.kist.re.kr/handle/201004/37072
ISSN
0168-3659
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KIST Publication > Article
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