PHARMACOKINETIC STUDY OF PACLITAXEL FROM VARIOUS BIODEGRADABLE POLYMERS

Title
PHARMACOKINETIC STUDY OF PACLITAXEL FROM VARIOUS BIODEGRADABLE POLYMERS
Authors
김시은박귀덕한동근
Keywords
PHARMACOKINETIC; PACLITAXEL; BIODEGRADABLE POLYMERS
Issue Date
2010-01
Publisher
APMT 2010
Citation
, PS130
Abstract
For two decades, although many researchers have studied the efficacy of paclitaxel on many cells, little work has been reported on the importance of PTX release kinetic regarding inhibition of cell proliferation. This study aims to understand the release kinetics of PTX from biodegradable polymers (i.e., poly lactic-co-glycolic acid (PLGA), polycaprolactone (PCL), and poly L-lactic acid (PLLA)), with varying concentrations of PTX. Each polymer film with PTX was prepared using solution casting method. The HPLC analysis demonstrated that the release rate increased with the decreased concentration of PTX. Interestingly, the release rate of PCL was faster than other polymers at the same amount of paclitaxel (Fig 1a). The cumulative release of PTX was the least with PLLA through the entire time period. As shown in Fig 1b, the individual PTX release rate was considerably different with various amount of PTX released from PLGA. Interestingly, glass transition temperature (Tg) was quite different among the tested PTX/PLGA films determined by differential scanning calorimeter (DSC) (Fig 1c). While the exact mechanism is unclear at this time, there may exist some polymer-drug interactions within the polymer matrix. Therefore, it seems that the complete understanding of release mechanism is warranted for the applications in drug delivery carriers and stents.
URI
http://pubs.kist.re.kr/handle/201004/37110
Appears in Collections:
KIST Publication > Conference Paper
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